Read e-book online Analytical Method Development and Stability Studies of PDF

By Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu

ISBN-10: 3656948895

ISBN-13: 9783656948896

Master's Thesis from the 12 months 2011 within the topic drugs - Pharmacology, grade: 8.0, , direction: B.Pharm.,M.Pharm, language: English, summary: A opposite part excessive functionality liquid chromatographic technique (HPLC) has been built for the tactic improvement validation of Carvedilol in bulk and pharmaceutical formula by utilizing YMC PACK seasoned 4.6 X one hundred fifty mm (5µm Particle size). The cellular section used to be Buffer: Acetonitrile: (70:30) and pH was once adjusted to two pumped at a move expense of one ml/min and the eluents have been monitored at 320nm. Linearity was once got within the focus diversity of 10-90 μg/ml. The retention time of Carvedilol used to be discovered to be 3.2 minute. the tactic used to be tested for specificity, accuracy, precision, linearity, and restrict of detection, restrict of quantification, robustness and solubility balance. LOD and LOQ have been discovered to be 0.001 μg/ml and 0.011μg/ml respectively. the strategy was once statistically confirmed and RSD was once chanced on to be lower than 2% indicating excessive measure of accuracy and precision of the proposed HPLC strategy. balance research document published that the drug is vulnerable for acidic, alkaline, oxidative, photolytic and UV degradation. The drug is strong to thermal degradation. extra over the degradants have been good separated from its API. as a result of its simplicity, rapidness, excessive precision and accuracy, the proposed HPLC approach can be used for choosing Carvedilol in bulk drug samples or in pharmaceutical dosage forms.

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Analytical Method Development and Stability Studies of Carvedilol by Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu


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